Lock file for access on windows

Using portalocker we can lock a file for access through the following way:

f=open("M99","r+")
portalocker.lock(f,portalocker.LOCK_EX)

The lock over the file can be removed using

f.close()  #or
portalocker.unlock(file)   #needs `file` ie reference to file it locked ..pretty obvious too

Can this same thing be done by any other way in python wherein

1)We can lock the file for access

2)Forget the reference to file or forget f in this case and using only filenamei.e M99 in this case detect if it has a lock and unlock it.

I cannot save f or file object so cant use pickle or something as well.Is there a way using python or some win32api or something?

Sort of make this asynchronous somehow?